OMIP‐053: Identification, Classification, and Isolation of Major FoxP3 Expressing Human CD4 + Treg Subsets
نویسندگان
چکیده
منابع مشابه
CD4⁺Foxp3⁺ Treg and its ICOS⁺ Subsets in Patients with Myocardial Infarction
Background: Atherosclerosis is a multifactorial disorder with chronic inflammatory conditions in which immune cells play a significant role in its pathogenic process. Regulatory T cells (Treg), as a part of immune system, are involved in controlling autoimmune and inflammatory diseases. Quantitative and/or functional alteration of Tregs has been shown to play an atheroprotective role and may al...
متن کاملcd4⁺foxp3⁺ treg and its icos⁺ subsets in patients with myocardial infarction
background: atherosclerosis is a multifactorial disorder with chronic inflammatory conditions in which immune cells play a significant role in its pathogenic process. regulatory t cells (treg), as a part of immune system, are involved in controlling autoimmune and inflammatory diseases. quantitative and/or functional alteration of tregs has been shown to play an atheroprotective role and may al...
متن کاملFunctionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells.
FOXP3+ regulatory T (Treg) cells are a broadly acting and potent anti-inflammatory population of CD4+ T cells essential for maintaining immune homeostasis and preventing debilitating autoimmunity. Based on chemokine receptor expression, we identified distinct populations of Treg cells in human blood expected to colocalize with different Th cell subsets. Although each population was functionally...
متن کاملIncreased Circulating Th17 but Decreased CD4+Foxp3+ Treg and CD19+CD1dhiCD5+ Breg Subsets in New-Onset Graves' Disease
Th17 and regulatory lymphocyte subsets such as Tregs and Bregs have been reported to play important roles in autoimmune diseases. The aim of this work was to perform quantitative studies of circulating Th17, Tregs, and Bregs in patients with new-onset Graves' disease (GD). Twenty GD patients and 20 healthy controls were involved in this study. Blood samples were taken for flow cytometry detecti...
متن کاملCombining FoxP3 and Helios with GARP/LAP markers can identify expanded Treg subsets in cancer patients
Regulatory T cells (Tregs) comprise numerous heterogeneous subsets with distinct phenotypic and functional features. Identifying Treg markers is critical to investigate the role and clinical impact of various Treg subsets in pathological settings, and also for developing more effective immunotherapies. We have recently shown that non-activated FoxP3-Helios+ and activated FoxP3+/-Helios+ CD4+ T ...
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ژورنال
عنوان ژورنال: Cytometry Part A
سال: 2018
ISSN: 1552-4922,1552-4930
DOI: 10.1002/cyto.a.23704